Atg7 (ATG7)

英文名:Rabbit Monoclonal Antibody
Cas号:
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别 名 ATG7 antibody, APG7-LIKE antibody, APG7L antibody, DKFZp434N0735 antibody, GSA7 antibody, Ubiquitin-like modifier-activating enzyme ATG7 antibody, Ubiquitin-activating enzyme E1-like protein antibody
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】Autophagy is a process of bulk degradation
of cytoplasmic components by the lysosome/vacuole and has
a significant relationship to several
neurodegenerative disorders and myopathies in mammals
(1). Atg7 (Apg7) is a unique E1 enzyme that is essential
for both the Apg12p- and Apg8p-modification systems, and
it plays indispensable roles in autophagy (2). A
new molecular pathway has been defined, in which
activation of the receptor-interacting protein (a
serine-threonine kinase) and Jun amino-terminal
kinase induced cell death with the morphology of
autophagy. Autophagic death required Atg7 and beclin 1
and was induced by caspase-8 inhibition (3).


Recommended Applications

WB, ICC
Applications and Recommended Dilution Factors

WB: 1:10,000 - 50,000
ICC: 1:100 - 250
Species Reactivity *

Human, Mouse, Rat

*Species cross-reactivity is based on WB analysis.

Products Data
Western blot analysis on (A) 293T, (B) HepG2, and (C)
Jurkat cell lysates using anti-Atg7 RabMAb (cat. #5146-1).

Immunofluorescent staining of HeLa cells using
anti-Atg7 RabMAb (cat.# 5146-1).

Specificity

A synthetic peptide corresponding to residues in human
Atg7 was used as an immunogen.
性状 【反应特异性】Human , Mouse , Rat
【克隆 ID】EPR6251
【用途】WB , ICC
【抗原分子量】72kDa
贮存 Storage Condition and Buffer Store at -20 °C. Antibody buffer, 0.01% sodium azide, 50% Glycerol and 0.05% BSA. Stable for 12 months from date of receipt
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