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【产品介绍】Integrins are heterodimeric integral
membrane proteins composed of an alpha chain and a
beta chain. The I-domain containing CD51 / Integrin
alpha-V undergoes post-translational cleavage to
yield disulfide-linked heavy chain (125 kDa) and light
chain (25 kDa), which combine with multiple integrin
beta chains to form different integrins. Among the
known associating beta chains (beta chains 1,3,5,6,
and 8; ITGB1, ITGB3, ITGB5, ITGB6, and ITGB8), each
can interact with extracellular matrix ligands; the
CD51 / Integrin alpha-V, perhaps the most studied of
these, is referred to as the Vitronectin receptor (VNR).
In addition to adhesion, many integrins are known
to facilitate signal transduction (1).
Recommended Applications
WB, FC
Applications and Recommended Dilution Factors WB: 1:1,000 - 10,000
FC: 1:10 - 100
Species Reactivity * Human, Mouse, Rat *Species cross-reactivity is based on WB analysis
Products Data
Western blot analysis on (A) A549, (B) A431, (C) C6,
(D) RAW264.7, (E) PC-12, and (F) NIH/3T3 cell lysates
using anti-CD51 / Integrin alpha-V RabMAb (cat. #3919-1). Flow cytometric analysis of permeabilized A549 cells
using anti-CD51 / Integrin alpha-V RabMAb (red)
(catalog # 3919-1) or a rabbit IgG (negative) (green).
Specificity
A synthetic peptide corresponding to residues in
the intracellular domain of human CD51 / Integrin
alpha-V was used as an immunogen. |
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