【产品介绍】Carcinoembryonic antigen-related cell
adhesion molecule (CEACAM) proteins, members of
the immunoglobulin (Ig) superfamily, are involved
in cell-cell recognition and modulate cellular
processes that range from the shaping of tissue
architecture and neovascularization to the regulation
of insulin homeostasis and T-cell proliferation (1).
CEACAM1 is a type I membrane glycoprotein that plays a
role in intercellular adhesion to inhibit tumor
development as a bacterial adhesin (2). Moreover, CEACAM1
is an active regulator of cell signaling by modulating
the insulin or EGF receptor pathways in epithelial cells
or the Zap-70 pathway in hematopoietic cells (2). It
is known to be a tumor suppressor, since CEACAM1
is down-regulated in most epithelial cell cancers and
T-cell leukemias (3).
Recommended Applications
WB, IHC
Applications and Recommended Dilution Factors WB: 1:1,000-10,000
IHC: 1:100 - 250
Species Reactivity Human
Products Data
Western blot analysis on (A) HepG2, (B) fetal liver,
and (C) A549 cell lysates using anti-CEACAM1
RabMAb (cat. # 2928-1) Immunohistochemical staining of paraffin-embedded
human kidney tissue using anti-CEACAM1 RabMAb (cat. #2928-1). Immunohistochemical staining of paraffin-embedded
human liver tissue using anti-CEACAM1 RabMAb (cat. #2928-1).
Specificity
A synthetic peptide corresponding to residues near
the N-terminus of human CEACAM1 was used as an immunogen. |
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