【产品介绍】Carcinoembryonic antigen-related cell adhesion molecule (CEACAM) proteins, members of the immunoglobulin (Ig) superfamily, are involved in cell-cell recognition and modulate cellular processes that range from the shaping of tissue architecture and neovascularization to the regulation of insulin homeostasis and T-cell proliferation (1). CEACAM1 is a type I membrane glycoprotein that plays a role in intercellular adhesion to inhibit tumor development as a bacterial adhesin (2). Moreover, CEACAM1 is an active regulator of cell signaling by modulating the insulin or EGF receptor pathways in epithelial cells or the Zap-70 pathway in hematopoietic cells (2). It is known to be a tumor suppressor, since CEACAM1 is down-regulated in most epithelial cell cancers and T-cell leukemias (3). Recommended Applications
WB, IHC Applications and Recommended Dilution Factors WB: 1:1,000-10,000 IHC: 1:100 - 250 Species Reactivity Human Products Data
Western blot analysis on (A) HepG2, (B) fetal liver, and (C) A549 cell lysates using anti-CEACAM1 RabMAb (cat. # 2928-1) Immunohistochemical staining of paraffin-embedded human kidney tissue using anti-CEACAM1 RabMAb (cat. #2928-1). Immunohistochemical staining of paraffin-embedded human liver tissue using anti-CEACAM1 RabMAb (cat. #2928-1). Specificity
A synthetic peptide corresponding to residues near the N-terminus of human CEACAM1 was used as an immunogen. |