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GSK3 alpha/beta Phospho (pY279)/(pY216) (GSK3A)

英文名：GSK3 alpha/beta Phospho (pY279)/(pY216) (GSK3A)
Cas号：
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别 名 GSK3A antibody, DKFZp686D0638 antibody, Glycogen synthase kinase-3 alpha antibody, antibody
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】Glycogen synthases kinase 3 alpha (GSK3-α) is
a multifunctional Serine/Threonine protein kinase, one
of two isoforms of GSK3 (1). Originally identified as
a regulator of glycogen synthase, it has been shown to
be involved in the hormonal control of several
regulatory factors and transcription factors.
GSK3-α activity is down regulated by phosphorylation
on Serine 21 by PKB, or activated by phosphorylation
on Tyrosine 279 (2). Insulin inactivates GSK3-α by
rapid phosphorylation which leads to activation of
Glycogen Synthase in the cells (3). GSK3-α activitiy
has been linked to a pathogenic mechanism in
Alzheimer's disease (4). GSK3 beta) plays a key role
in insulin and Wnt signaling, phosphorylating
downstream targets by default, and becoming
inhibited following the extracellular signaling event (5).

Recommended Applications
WB, IHC, ICC, IP
Applications and Recommended Dilution Factors
WB: 1:500 - 2000
IHC: 1:100
ICC: 1:250
IP: 1:40
Species Reactivity *
Human, Mouse, Rat
*Cross reactivity determined by western blot only.

Products Data

A. Western blot analysis on 293 cell lysates
using anti-Phospho-GSK3a/b (pY279/pY216) RabMAb
(cat. #2309-1), 1:2000 dilution. Cells were
either (A) untreated (B) treated with AP

B. Immunohistochemical analysis of parafffin-embedded
human brain using anti-GSK3aGSK3b (pY279)/(pY216)
RabMAb (cat. # 2309-1).

Specificity
A phospho specific peptide corresponding to
residues surrounding tyrosine 279 in human GSK3a
and tyrosine 216 in human GSKb was used as an
immunogen. This antibody detects both GSKα
phosphorylated on tyrosine 279 and GSK3β phosphorylyated
on tyrosine 216.
性状 【产品类型】Rabbit Monoclonal Antibody
【反应特异性】Human , Mouse , Rat
【克隆 ID】EPR933Y
【用途】WB , IHC , ICC , IP
【产品性状】
【阳性对照】
【产品浓度】
【细胞定位】
【抗原分子量】47/51kDa
贮存 Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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