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Recombinant Human Noggin (CHO-expressed)

英文名：
Cas号：
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Human Noggin (CHO-expressed) 是骨形态发生蛋白 (BMPs) 的拮抗剂，对 hBMP-4 有很高的亲和性，而对 hBMP-7 的亲和性较低，它在骨骼发展过程中是必不可少的。
Synonyms
rHuNoggin; NOG ; 重组人头蛋白 (CHO 细胞表达)
Species
Human

Source
CHO

Accession
Q13253

Gene ID
9241

Molecular Weight
29-31 kDa

AA Sequence
QHYLHIRPAP SDNLPLVDLI EHPDPIFDPK EKDLNETLLR SLLGGHYDPG FMATSPPEDR PGGGGGAAGG AEDLAELDQL LRQRPSGAMP SEIKGLEFSE GLAQGKKQRL SKKLRRKLQM WLWSQTFCPV LYAWNDLGSR FWPRYVKVGS CFSKRSCSVP EGMVCKPSKS VHLTVLRWRC QRRGGQRCGW IPIQYPIISE CKCSC

Biological Activity
The ED50 is <2.5 ng/mL as measured by ATDC5 cells.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human Noggin (CHO-expressed) (rHuNoggin) to 100 µg/mL using ddH2O or diluted with PBS.

Storage & Stability
Lyophilized recombinant Human Noggin (CHO-expressed) (rHuNoggin) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
Human Noggin protein has 205 amino acids (residues 28-232) after removal of its signal sequence (residues 1-27) and is secreted as a glycosylated, covalently linked homodimer, binds with high affinity to hBMP-4, and with lower affinity to hBMP-7 and acts as an antagonist of bone morphogenetic proteins (BMPs)[1]. Noggin is essential for proper skeletal development; excess BMP activity in the Noggin null mutant results in excess cartilage and failure to initiate joint formation[2].
贮存
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