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Recombinant Mouse Interleukin-6

英文名：
Cas号：
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货号 规格 货期 库存 价格 会员价 订购
1308132584-2 μg 0 ￥1540 请登录
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1308132584-10 μg 0 ￥3960 请登录
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Mouse Interleukin-6 是一种多功能细胞因子，可调节各种免疫和炎症反应。
Synonyms
rMuIL-6; BSF-2; CDF; Hybridoma growth factor; IFN-beta-2
Species
Mouse

Source
E. coli

Accession
P08505

Gene ID
16193

Molecular Weight
Approximately 21.7 kDa

AA Sequence
MFPTSQVRRG DFTEDTTPNR PVYTTSQVGG LITHVLWEIV EMRKELCNGN SDCMNNDDAL AENNLKLPEI QRNDGCYQTG YNQEICLLKI SSGLLEYHSY LEYMKNNLKD NKKDKARVLQ RDTETLIHIF NQEVKDLHKI VLPTPISNAL LTDKLESQKE WLRTKTIQFI LKSLEEFLKV TLRSTRQT

Biological Activity
The ED50 is <0.02 ng/mL as measured by murine 7TD1 cells, corresponding to a specific activity of >5 × 107 units/mg.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS, pH 7.4.

Endotoxin Level
<1 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Murine Interleukin-6 (rMuIL-6) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1 % BSA.

Storage & Stability
Lyophilized recombinant Murine Interleukin-6 (rMuIL-6) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
Interleukin-6 (IL-6) is one of the most important mediators of the acute phase reaction in liver[1]. Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue injuries, contributes to host defense through the stimulation of acute phase responses, hematopoiesis, and immune reactions. IL-6 promotes specific differentiation of naïve CD4+ T cells, thus performing an important function in the linking of innate to acquired immune response. IL-6, in combination with transforming growth factor (TGF)-β, is indispensable for Th17 differentiation from naïve CD4+ T cells, but that IL-6 also inhibits TGF-β-induced Treg differentiation[2].
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