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Recombinant Mouse Basic Fibroblast Growth Factor
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| 性状 | Recombinant Mouse Basic Fibroblast Growth Factor 是一种内皮细胞和成纤维细胞的有效有丝分裂原和化学诱导剂。
Synonyms rMubFGF; HBGF-2; FGF-2; FGF-b; FGF-basic ; 重组小鼠碱性成纤维细胞生长因子 Species Mouse Source E. coli Accession P15655 Gene ID 14173 Molecular Weight Approximately 16.5 kDa AA Sequence MPALPEDGGA AFPPGHFKDP KRLYCKNGGF FLRIHPDGRV DGVREKSDPH VKLQLQAEER GVVSIKGVCA NRYLAMKEDG RLLASKCVTE ECFFFERLES NNYNTYRSRK YSSWYVALKR TGQYKLGSKT GPGQKAILFL PMSAKS Biological Activity The ED50 is <1.0 ng/mL as measured by murine balb/c 3T3 cells, corresponding to a specific activity of >1.0 × 106 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS, pH 7.4. Endotoxin Level <1 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Murine Basic Fibroblast Growth Factor (rMubFGF) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1 % BSA. Storage & Stability Lyophilized recombinant Murine Basic Fibroblast Growth Factor (rMubFGF) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Basic fibroblast growth factor (bFGF) is a heparin-binding mitogen for mesoderm-derived cells, also acts as a mitogen, differentiation inducing and maintenance factor for many neuroectodermal cells including glial cells, neurons, paraneurons, and their tumor counterparts. The molecule is expressed in several types of neuroectodermal cells. bFGF occurs in many neuronal target tissues, and can prevent ontogenetic as well as lesion-induced neuron death[1]. In vitro, basic fibroblast growth factor induces an angiogenic phenotype in endothelial cells, which includes chemotaxis, mitogenesis, protease production, beta-integrin expression, and tube formation in three-dimensional gels. It acts by binding to specific tyrosine kinase receptors and to cell-associated heparan sulfate proteoglycans[2]. |
| 贮存 |
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- Recombinant Mouse Basic Fibroblast Growth Factor
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