本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的，不可用于人类或动物的临床诊断或者治疗，非药用，非食用。
Recombinant Mouse Interleukin-1 beta
| 别 名 | |
| Cas号 | |
| M D L | |
| 分子式 | |
| 分子量 | |
| 产品参数 | |
| 性状 | Recombinant Mouse Interleukin-1 beta 是由单核细胞，组织巨噬细胞，角质形成细胞和其他上皮细胞产生的一种促炎细胞因子。
Synonyms rMuIL-1β; Catabolin; IL1F2; IL-1 beta; IL1B Species Mouse Source E. coli Accession P10749 Gene ID 16176 Molecular Weight Approximately 17.5 kDa AA Sequence MVPIRQLHYR LRDEQQKSLV LSDPYELKAL HLNGQNINQQ VIFSMSFVQG EPSNDKIPVA LGLKGKNLYL SCVMKDGTPT LQLESVDPKQ YPKKKMEKRF VFNKIEVKSK VEFESAEFPN WYISTSQAEH KPVFLGNNSG QDIIDFTMES VSS Biological Activity The ED50 is <2.0 pg/mL as measured by mouse D10S cells, corresponding to a specific activity of >5.0 × 108 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Murine Interleukin-1 beta (rMuIL-1β) to 100 µg/mL using ddH2O or diluted with PBS. Storage & Stability Lyophilized recombinant Murine Interleukin-1 beta (rMuIL-1β) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background IL-1β is a potent proinflammatory cytokine, whose levels are increased in patients with alcoholic liver disease (ALD). IL-1β is produced as inactive pro–IL-1β (encoded by pro-Il-1b) in response to inflammatory stimuli, including both microbial products and endogenous danger-associated molecules. IL-1β gene expression and synthesis of pro-IL-1β occurs after activation of pattern recognition receptors (PRRs). Inflammatory stimuli also drive activation of cytosolic CARD and PYHIN domain-containing PRRs that recruit ASC and caspase-1 (Casp-1) to assemble into the multiprotein complex inflammasome. Pro-Casp-1 (encoded by pro-Casp-1), activated by the inflammasome, cleaves pro–IL-1β into the bioactive IL-1β. IL-1β acts in an autocrine/paracrine manner via the type I IL-1 receptor (IL-1R1). Activation of IL-1R1 is inhibited by its binding to the IL-1 receptor antagonist (IL-1Ra), a naturally occurring cytokine whose function is to prevent the biologic response to IL-1. Treatment with IL-1Ra significantly improves symptoms in patients with rheumatoid arthritis or autoinflammatory syndromes; unlike anti-TNF therapy, it is not associated with infectious complications[1]. |
| 贮存 |
- Recombinant Mouse Granulocyte-Macrophage Colony Stimulating Factor (CHO-expressed)
- Recombinant Mouse Insulin-like Growth factor-1
- Recombinant Mouse Interferon-gamma
- Recombinant Mouse Interleukin-1 alpha
- Recombinant Mouse Interleukin-1 beta
- Recombinant Mouse Interleukin-10 (CHO-expressed)
- Recombinant Mouse Interleukin-11 (HEK293-expressed)
- 抗氧化剂B215
沪公网安备 31012002003054号