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Recombinant Human Neurotrophin-4
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性状 | Recombinant Human Neurotrophin-4 属于神经营养因子家族中的一员,能够与两种不同的受体结合,高亲和性受体 TrkB 和低亲和性受体 p75NTR。
Synonyms rHuNT-4; NT-5; NTF4; NTF5 ; 重组人神经营养因子-4 Species Human Source E. coli Accession P34130 Gene ID 4909 Molecular Weight Approximately 28.1 kDa AA Sequence MGVSETAPAS RRGELAVCDA VSGWVTDRRT AVDLRGREVE VLGEVPAAGG SPLRQYFFET RCKADNAEEG GPGAGGGGCR GVDRRHWVSE CKAKQSYVRA LTADAQGRVG WRWIRIDTAC VCTLLSRTGR A Biological Activity The ED50 is <5 μg/mL as measured by C6 cells, corresponding to a specific activity of >2.0 × 102 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against 50 mM acetic acid. Endotoxin Level <0.3 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Neurotrophin-4 (rHuNT-4) to 50 μg/mL using ddH2O or 50 mM acetic acid. Storage & Stability Lyophilized recombinant Human Neurotrophin-4 (rHuNT-4) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Neurotrophin-4 (NT-4) is a member of the well-studied family of neurotrophins that regulate the development of neuronal networks by participating in the growth of neuronal processes, synaptic development and plasticity, neuronal survival, differentiation, as well as myelination. Neurotrophin-4 binds with two distinct receptors: TrkB, high affinity receptor and p75 low-affinity neurotrophin receptor (p75NTR)[1]. |
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