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Recombinant Human B7-H2/ICOSLG, His (HEK293-expressed)

英文名：
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308132836-10 μg 0 ￥2200 请登录
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1308132836-50 μg 0 ￥4200 请登录
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Human B7-H2/ICOSLG, His (HEK293-expressed) 是 HEK293 细胞中产生的 C-末端含 His 标签的多肽链。ICOSLG 属于共刺激分子 B7 家族。
Synonyms
rHuB7-H2/ICOSLG, His; B7 homolog 2; B7RP-1; CD275
Species
Human

Source
HEK 293

Accession
O75144

Gene ID
23308

Molecular Weight
45-55 kDa

AA Sequence
DTQEKEVRAM VGSDVELSCA CPEGSRFDLN DVYVYWQTSE SKTVVTYHIP QNSSLENVDS RYRNRALMSP AGMLRGDFSL RLFNVTPQDE QKFHCLVLSQ SLGFQEVLSV EVTLHVAANF SVPVVSAPHS PSQDELTFTC TSINGYPRPN VYWINKTDNS LLDQALQNDT VFLNMRGLYD VVSVLRIART PSVNIGCCIE NVLLQQNLTV GSQTGNDIGE RDKITENPVS TGEKNAATWS HHHHHHHHHH

Biological Activity
1 µg/mL (100 µL/well) of immoblized recombinant human B7-H2/ICOSLG-His can bind human ICOS-Fc with a linear range of 2.29-185.2 ng/mL.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS, 5% trehalose and mannitol.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human B7-H2/ICOSLG, His (HEK293-expressed) (rHuB7-H2/ICOSLG, His) to 100 µg/mL using ddH2O or diluted with PBS.

Storage & Stability
Lyophilized recombinant Human B7-H2/ICOSLG, His (HEK293-expressed) (rHuB7-H2/ICOSLG, His) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
As a member of the B7 family, inducible co-stimulator ligand (ICOSLG) expressed on tumor cell has been reported to have an important role in tumor immunity. As the counter ligand of ICOS, a CD28-related molecule, ICOSLG is expressed on professional antigen-presenting cell (APCs; such as dendritic cells (DCs) and B cells) and on some tumor cells (such as glioma cells and gastric carcinoma cells). ICOSLG is the only B7 family member that preferentially co-stimulates type 2T helper cell (Th2) responses, and interestingly, this unique molecule has a critical role in antitumor immunity. ICOSLG expression on solid tumors (implanted-transfected tumors) aids in both NK mediated and CD8+ cytotoxic T cell (CTL) activation and killing. Several studies using ICOSLG-transfected solid tumor cell lines found that ICOSLG induced CD8+ cytotoxic lymphocyte-mediated tumor regression[1].
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