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Recombinant Human Angiotensin-Converting Enzyme 2, C-Fc (HEK293-expressed)
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| 性状 | Recombinant Human Angiotensin-Converting Enzyme 2, C-Fc (HEK293-expressed) 是一种SARS-CoV-2受体。Angiotensin-Converting Enzyme 2能有效地将血管紧张素II水解成血管紧张素。这种作用的结果是ACE2参与肾素-血管紧张素系统。
Synonyms Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2 ; 重组人血管紧张素转换酶 2，C-Fc (HEK293 表达) Species Human Source HEK 293 Accession Q9BYF1 Gene ID 59272 Molecular Weight 110-140 kDa AA Sequence QSTIEEQAKT FLDKFNHEAE DLFYQSSLAS WNYNTNITEE NVQNMNNAGD KWSAFLKEQS TLAQMYPLQE IQNLTVKLQL QALQQNGSSV LSEDKSKRLN TILNTMSTIY STGKVCNPDN PQECLLLEPG LNEIMANSLD YNERLWAWES WRSEVGKQLR PLYEEYVVLK NEMARANHYE DYGDYWRGDY EVNGVDGYDY SRGQLIEDVE HTFEEIKPLY EHLHAYVRAK LMNAYPSYIS PIGCLPAHLL GDMWGRFWTN LYSLTVPFGQ KPNIDVTDAM VDQAWDAQRI FKEAEKFFVS VGLPNMTQGF WENSMLTDPG NVQKAVCHPT AWDLGKGDFR ILMCTKVTMD DFLTAHHEMG HIQYDMAYAA QPFLLRNGAN EGFHEAVGEI MSLSAATPKH LKSIGLLSPD FQEDNETEIN FLLKQALTIV GTLPFTYMLE KWRWMVFKGE IPKDQWMKKW WEMKREIVGV VEPVPHDETY CDPASLFHVS NDYSFIRYYT RTLYQFQFQE ALCQAAKHEG PLHKCDISNS TEAGQKLFNM LRLGKSEPWT LALENVVGAK NMNVRPLLNY FEPLFTWLKD QNKNSFVGWS TDWSPYADQS IKVRISLKSA LGDKAYEWND NEMYLFRSSV AYAMRQYFLK VKNQMILFGE EDVRVANLKP RISFNFFVTA PKNVSDIIPR TEVEKAIRMS RSRINDAFRL NDNSLEFLGI QPTLGPPNQP PVS Biological Activity Binding ability is measured by functional ELISA, 10 μg/mL (100 µL/well) of immoblized recombinant human Angiotensin-Converting Enzyme 2, C-Fc can bind to S Proetin RBD-SD1, C-mFc. The ED50 of recombinant S Protein RBD-SD1, C-mFc is 15.5 ng/mL. Appearance Solution. Formulation Supplied as a 0.2 μm filter solution of 20 mM Tris-HCl, 1 mM ZnCl2, 10% Glycerol, pH 7.4. Endotoxin Level <1 EU/μg, determined by LAL method. Reconstitution N/A Storage & Stability Recombinant Human Angiotensin-Converting Enzyme 2, C-Fc (HEK293-expressed) (rHuACE-2, C-Fc) is stored at -20°C. It is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Shipping with dry ice. Background Angiotensin-Converting Enzyme 2 (ACE2) is a type I integral membrane protein which functions as a carboxypeptidase, cleaving a single hydrophobic/basic residue from the C-terminus of its substrates. ACE2 efficiently hydrolyses the potent vasoconstrictor angiotensin II to angiotensin. It is a consequence of this action that ACE2 participates in the renin-angiotensin system. However, ACE2 also hydrolyses dynorphin A (1–13), apelin-13 and des-Arg9 bradykinin. The role of ACE2 in these peptide systems has yet to be revealed. A physiological role for ACE2 has been implicated in hypertension, cardiac function, heart function and diabetes, and as a receptor of the severe acute respiratory syndrome coronavirus. This paper reviews the biochemistry of ACE2 and discusses key findings such as the elucidation of crystal structures for ACE2 and testicular ACE and the development of ACE2 inhibitors that have now provided a basis for future research on this enzyme. |
| 贮存 |
- Recombinant Nucleocapsid Protein NTD domain, His
- Recombinant Nucleocapsid Protein CTD domain, His
- Recombinant Envelope, His
- Recombinant Human Angiotensin-Converting Enzyme 2, His (HEK293-expressed)
- Recombinant Human Angiotensin-Converting Enzyme 2, C-Fc (HEK293-expressed)
- Recombinant Human Angiotensin-Converting Enzyme 2, C-mFc (HEK293-expressed)
- Recombinant Human Mannan-binding lectin serine protease 1, His (HEK293-expressed)
- Recombinant Human 14-3-3 protein epsilon, N-GST
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