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Caveolin 2 Phospho (pY19) (CAV2)
英文名：Rabbit Monoclonal Antibody
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| 货号 | 规格 | 货期 | 库存 | 价格 | 会员价 | 订购 |
| 1308113403-100ul | 现货 | 0 | ￥0 | 请登录 |
| 别 名 | CAV2 antibody, CAV antibody, MGC12294 antibody, Caveolin-2 antibody, antibody |
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| 产品参数 | 【产品介绍】Caveolins (Caveolin 1, 2, and 3) are a family
of caveolae-associated integral membrane proteins. Caveolae are cholesterol/sphingolipid-rich microdomains of the plasma membrane that have been implicated in signal transduction and vesicular trafficking (1). Caveolin 2 is a principal component of caveolae membranes. It interacts directly with heterotrimeric guanine nucleotide binding proteins (G proteins) and can functionally regulate their activity. Caveolins 1 and 2 are similar in most respects; however, they differ in their functional interactions with heterotrimeric G proteins, possibly explaining why Caveolin-1 and -2 are coexpressed within a single cell (2). Caveolin-2 is up-regulated in response to the mechanical injury of differentiated PC12 cells, which is strictly dependent on continued treatment with NGF. Both Caveolin-1 and -2 are more abundantly expressed in white adipose tissue and are induced during adipocyte differentiation. Robust expression of Caveolin-1 and -2 is also observed along the entire cell surface of DRG neurons, including high levels on growth cones (1). Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3 (2). Recommended Applications WB, FC Applications and Recommended Dilution Factors WB: 1:1,000 - 10,000 FC: 1:10 - 100 Species Reactivity * Human *Species cross-reactivity is based on WB analysis. Products Data Western blot analysis on HUVEC cell lysates using anti-Phospho-Caveolin 2 (pY19) RabMAb (cat. #3873-1). Cells were either (A) untreated (B) treated with pervanadate. Flow cytometric analysis of permeabilized HUVEC cells, untreated (green) or pervanadate-treated (red) using anti-Caveolin 2 Phospho (pY19) RabMAb (catalog # 3873-1), and pervanadate-treated HUVEC cells using the same antibody preincubated with phospho-Caveolin 2 Phospho (pY19) peptide (blue) or non-phospho-Caveolin 2 Phospho (pY19) peptide (orange). Specificity A phospho specific peptide corresponding to residues surrounding tyrosine 19 of human Caveolin 2. This antibody detects Caveloin 2 phosphorylated at tyrosine 19. |
| 性状 | 【反应特异性】Human
【克隆 ID】EPR2220(3) 【用途】WB , FC 【抗原分子量】20kDa |
| 贮存 | Storage Condition and Buffer Store at -20° C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
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