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Fc gamma RIIb/CD32 Phospho (pY292) (FCGR2B)

英文名：Rabbit Monoclonal Antibody
Cas号：
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别 名 FCGR2B antibody, CD32 antibody, CD32B antibody, FCG2 antibody, FCGR2 antibody, IGFR2 antibody, Low affinity immunoglobulin gamma Fc region receptor II-b antibody, CDw32 antibody, Fc-gamma RII-b antibody
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】Low affinity IgG Fc receptor gamma II
(Fc-gamma II), also known as CD32, is a member of
the immunoreceptor tyrosine-based activating/
inhibitory motif (ITAM/ITIM) family. Fc gamma receptors
play a critical role in immunity by linking the IgG
antibody mediated response with the regulatory functions
of the immune system (1). Three classes of Fc gamma
receptor exist; Fc gamma RI (CD64, a high
affinity receptor), Fc gamma RII, and RIII (CD32 and
CD16 respectively, both low affinity receptors). Fc
gamma RIIa is an activating receptor, while RIIb1,
RIIb2, and RIIb3 are inhibitory receptors generated
by alternative splicing (1-2). Fc gamma RIIa is critical
for antigen-presenting-cell activation and Fc gamma
RIIb downregulates B-cell functions (3). Coligation
of FcgammaRIIb with the B-cell antigen receptor
(BCR) results in the abrogation of B-cell activation
and become phosphorlyated by protein tyrosine kinase
(PTK) (4)


Recommended Applications

WB, IP
Applications and Recommended Dilution Factors

WB: 1:50,000 - 100,000
IP: 1:70
Species Reactivity *

Human, Mouse

*Cross reactivity determined by western blot only,
mouse reactivity predicted based on sequence analysis

Products Data

A. Western blot analysis on Daudi cell lysates
using anti-Phospho-Fc gamma RIIb (py292) RabMAb
(cat. #2308-1), 1:100,000 dilution. Cells were
either (A) untreated (B) treated with pervanadate.

Specificity

A phospho specific peptide corresponding to
residues surrounding tyrosine 292 of human Fc gamma
RIIb. This antibody detects Fc gamma RIIb phosphorylated
on tyrosine 292.
性状 【反应特异性】Human , Mouse
【克隆 ID】EP926Y
【用途】WB , IP
【抗原分子量】40/44kDa
贮存 Storage Condition and Buffer Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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