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【产品介绍】The exact function of FTO is not known.
Studies in mice suggest that it may be involved in
nucleic acid demethylation, and that its mRNA level
is regulated by feeding and fasting. Studies of type
2 diabetes indicate FTO is related to
diabetes susceptibility. Mutation in this protein has
been associated with growth retardation,
developmental delay, coarse facies, and early death (1).
Recommended Applications
WB, IHC, ICC, FC
Applications and Recommended Dilution Factors WB: 1:1,000 - 10,000
IHC: 1:50 - 100
ICC: 1:50 - 100
FC: 1:10 - 100
Species Reactivity * Human *Species cross-reactivity is based on WB analysis. Products Data
Western blot analysis on (A) Molt-4, (B) 293T,
(C) SH-SY5Y, (D) BxPC-3, and (E) Caco-2 cell lysates
using anti-FTO RabMAb (cat. #5514-1).
Immunohistochemical analysis of paraffin-embedded
adrenal gland tissue using anti-FTO RabMAb (cat. #5514-1). Immunofluorescent staining of BxPC-3 cells using
anti-FTO RabMAb (cat. #5514-1). Specificity A synthetic peptide corresponding to residues at
the N-terminus of human FTO was used as an immunogen. |
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