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Growth Hormone Receptor (GHR)

英文名：Rabbit Monoclonal Antibody
Cas号：
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别 名 GHR antibody, GHBP antibody, Growth hormone-binding protein antibody, Serum-binding protein antibody
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】Growth Hormone Receptor is a member of the
type I cytokine receptor family, which is a
transmembrane receptor for growth hormone. Binding of
growth hormone to the receptor leads to
receptor dimerization and the activation of an
intra- and intercellular signal transduction pathway
leading to growth. Mutations in Growth Hormone Receptor
have been associated with Laron syndrome, also known as
the growth hormone insensitivity syndrome (GHIS), a
disorder characterized by short stature. In humans
and rabbits, but not rodents, growth hormone binding
protein (GHBP) is generated by proteolytic cleavage of
the extracellular ligand-binding domain from the
mature growth hormone receptor protein (1).


Recommended Applications

WB, ICC, FC
Applications and Recommended Dilution Factors

WB: 1:1,000 - 10,000
ICC: 1:100 - 250
FC: 1:100 - 500
Species Reactivity *

Human, Mouse, Rat

*Species cross-reactivity is based on WB analysis.

Products Data

Western blot analysis on (A) MCF-7, (B) BxPC-3, and
(C) fetal muscle lysates using anti-Growth Hormone
Receptor RabMAb (cat. #5342-1).

Flow cytometric analysis of permeabilized BxPC-3 cells
using anti-Growth Hormone Receptor RabMAb (red)
(catalog # 5342-1) or a rabbit IgG (negative) (green).

Specificity

A synthetic peptide corresponding to residues in
the intracellular domain in human Growth Hormone
Receptor was used as an immunogen.
性状 【反应特异性】Human , Mouse , Rat
【克隆 ID】EPR5291(2)
【用途】WB , ICC , FC
【抗原分子量】140kDa
贮存 Storage Condition and Buffer Store at -20° C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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