Alpha-Actinin 1

英文名:Alpha-Actinin 1
Cas号:
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别 名
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】Alpha-actinin is a ubiquitously
expressed protein found in numerous actin structures.
It consists of an N-terminal actin binding domain, a
central rod domain, a n d a C-terminal domain
a n d functions as a homodimer to cross-link
actin filaments. The rod domain determines the
distance between cross-linked actin filaments a n d
also serves as an interaction site f o r
several cytoskeletal a n d signaling proteins (1).
Alpha-actinins are a multigene family of four
actin-binding proteins related to dystrophin.
Alpha-actinin-1 a n d -4 (ACTN1, ACTN4) are non-muscle
isof o r ms version of ACTN. These isof o r m are
commonly expressed in filopodia, lamellipodia,
stress fibers, sites of adhesion a n d
intercellular contacts (2).

Recommended Applications
WB, ICC, FC, IP
Applications and Recommended Dilution Factors
WB: 1:500 - 1000
ICC: 1:100-250
FC: 1:40
IP: 1:40
Species Reactivity *
Human
* *Cross reactivity for this product was determined by western blot.

Products Data

A. Western blot analysis on (A) NIH 3T3 (B) human
skeletal muscle tissue (C) human heart tissue lysates
using anti-alpha-actinin 1 RabMAb (cat.# 2358-1),
dilution 1:1000.

Specificity
A synthetic peptide corresponding to residues on
the C-terminus of human Alpha-Actinin 1 was used as
an immunogen.
性状 【产品类型】Rabbit Monoclonal IgG
【反应特异性】Human , Mouse
【克隆 ID】EP2528Y
【用途】WB , ICC , FC , IP
【产品性状】
【阳性对照】
【产品浓度】
【细胞定位】
【抗原分子量】100 kDa
贮存 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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