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那他珠单抗
英文名：natalizuMab
Cas号：189261-10-7
Cas号：189261-10-7
检测信息查询
| 别 名 | Immunoglobulin G4,anti-(human integrin R4) (human-mouse monoclonal AN100226 c4-chain),disulfide with human-mouse monoclonal AN100226 light chain,dimer |
| Cas号 | 189261-10-7 |
| M D L | |
| 分子式 | C40H55N7O11S |
| 分子量 | 841.97 |
| 产品参数 | Description
Natalizumab is a recombinant, humanized monoclonal antibody, binds to α4β1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). Natalizumab can be used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease. Natalizumab is also the first targeted therapy which blocks an essential mechanism for lymphocyte entry to the CNS and thus prevents acute demyelinating relapses[1]. |
| 性状 | Natalizumab 是一种重组的人源化单克隆抗体，与 α4β1-整联蛋白 (α4β1-integrin) 结合并阻断其与血管细胞粘附分子 1 (VCAM-1) 的相互作用。Natalizumab 可用于治疗复发缓解型多发性硬化症和克罗恩氏病。Natalizumab 也可阻止淋巴细胞进入中枢神经系统，从而防止急性脱髓鞘复发 |
| 贮存 | SMILES [Natalizumab] Storage Please store the product under the recommended conditions in the Certificate of Analysis. References [1]. Hutchinson M. Natalizumab: A new treatment for relapsing remitting multiple sclerosis. Ther Clin Risk Manag. 2007 Jun;3(2):259-68. |
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