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Recombinant Human Amphiregulin
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| 性状 | Recombinant Human Amphiregulin (HEK293-expressed) 是 EGFR 的配体，对各种器官的上皮发育至关重要。
Synonyms rHuAmphiregulin; AR; AREG; Colorectum cell-derived growth factor; CRDGF ; 重组人双调蛋白 (HEK293 细胞表达) Species Human Source HEK 293 Accession P15514 Gene ID 374 Molecular Weight 15-20 kDa AA Sequence SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER CGEKSMKTHS MIDSSLSK Biological Activity The ED50 is <0.2 ng/mL as measured by 3T3 cells. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Amphiregulin (HEK293-expressed) (rHuAmphiregulin) to 100 µg/mL using ddH2O or diluted with PBS. Storage & Stability Lyophilized recombinant Human Amphiregulin (HEK293-expressed) (rHuAmphiregulin) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Amphiregulin, an EGF receptor (EGFR) ligand, and essential for epithelial development in various organs. Amphiregulin is suggested to act as a protective factor in a liver injury model. In mice model with bleomycin-induced pneumopathy, Recombinant Human Amphiregulin improves the survival rate and suppresses the degrees of inflammation and fibrosis and the number of TUNEL-positive cells in lung tissues. Recombinant Human Amphiregulin treatment enhances the activation of Akt and Erk in lung epithelial cells[1]. |
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