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Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor(P.pastoris-expressed)
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| 性状 | Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor (P.pastoris-expressed) 是造血生长因子和免疫调节剂
Synonyms rHuGM-CSF; CSF-2; MGI-1GM; Pluripoietin-alpha; Molgramostin; Sargramostim Species Human Source P. pastoris Accession P04141 Gene ID 1437 Molecular Weight 26-32 kDa AA Sequence MAPARSPSPS TQPWEHVNAI QEARRLLNLS RDTAAEMNET VEVISEMFDL QEPTCLQTRL ELYKQGLRGS LTKLKGPLTM MASHYKQHCP PTPETSCATQ IITFESFKEN LKDFLLVIPF DCWEPVQE Biological Activity The ED50 is <0.1 ng/mL as measured by TF-1 cells, corresponding to a specific activity of >1.0 × 107 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against 10 mM PB, pH 7.0. Endotoxin Level <1 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Granulocyte-Macrophage Colony Stimulating Factor (P.pastoris-expressed) (rHuGM-CSF) to 100 µg/mL using ddH2O. Storage & Stability Lyophilized recombinant Human Granulocyte-Macrophage Colony Stimulating Factor (P.pastoris-expressed) (rHuGM-CSF) is stored at -20°C. After reconstitution, it is stable at 4°C for 4 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Granulocyte-macrophage colony-stimulating factor (GM-CSF) is produced by a variety of cell types including T cells, macrophages, endothelial cells and fibroblasts upon receiving immune stimuli. It is an important hematopoietic growth factor and immune modulator. GM-CSF also has profound effects on the functional activities of various circulating leukocytes. GM-CSF stimulates multipotent progenitor cells depending on its concentration, the proliferation of macrophage progenitors at the lowest doses, followed by granulocyte, erythroid, eosinophil, megakaryocyte and multipotent progenitors. It also stimulates the differentiation of myeloid leukemic cells and controls eosinophil function in some instances[1][2]. GM-CSF also enhances the functionality of mature cells, such as neutrophils. In neutrophils, GM-CSF potentiates degranulation, the release of oxygen and nitrogen radical ions, phagocytosis, and inhibits apoptosis[3]. GM-CSF inhibition in some animal models of autoimmune diseases showed significant beneficial effects[4]. GM-CSF also has many pro-inflammatory functions and recent data implicates GM-CSF as a key factor in Th17 driven autoimmune inflammatory conditions[5]. |
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- Recombinant Human Granulocyte Colony Stimulating Factor
- Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor(CHO-expressed)
- Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor
- Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor(P.pastoris-expressed)
- Recombinant Human Heparin-binding EGF-like Growth Factor
- Recombinant Human Insulin-like Growth Factor-1
- Recombinant Human Insulin-like Growth factor-2
- Recombinant Human Insulin-like Growth Factor-Binding Protein 3
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