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Recombinant Human Granulocyte Colony Stimulating Factor
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| 性状 | Recombinant Human Granulocyte Colony Stimulating Factor是调节嗜中性粒细胞生成的多肽生长因子。
Synonyms rHuG-CSF; CSF-3; MGI-1G; Pluripoietin; Molgramostin; Sargramostim Species Human Source E. coli Accession P09919 Gene ID 1440 Molecular Weight Approximately 18.8 kDa AA Sequence MTPLGPASSL PQSFLLKCLE QVRKIQGDGA ALQEKLCATY KLCHPEELVL LGHSLGIPWA PLSSCPSQAL QLAGCLSQLH SGLFLYQGLL QALEGISPEL GPTLDTLQLD VADFATTIWQ QMEELGMAPA LQPTQGAMPA FASAFQRRAG GVLVASHLQS FLEVSYRVLR HLAQP Biological Activity The ED50 is <0.1 ng/mL as measured by M-NFS-60 cells, corresponding to a specific activity of >1.0 × 107 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against 25 mM Tris, pH 8.0. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Granulocyte Colony Stimulating Factor (rHuG-CSF) to 100 µg/mL using ddH2O. Storage & Stability Lyophilized recombinant Human Granulocyte Colony Stimulating Factor (rHuG-CSF) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Granulocyte Colony Stimulating Factor (G-CSF) is a cytokine that normally acts in the bone marrow microenvironment to stimulate blood cell formation. It selectively promotes growth and maturation of neutrophil progenitor cells. Granulocyte Colony Stimulating Factor receptors are present on precursor cells in the bone marrow. By binding to these receptors, Granulocyte Colony Stimulating Factor initiates proliferation and differentiation into mature granulocytes, and also stimulates bone marrow cell release into the circulation. In addition to growth promotion, Granulocyte Colony Stimulating Factor also effects phagocytosis, motility, bactericidal activity and surface molecule expression of neutrophils and monocytes[1][2]. G-CSF production is induced by several inflammatory stimuli that become rapidly elevated during infection such as interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNFα) and lipopolysaccaride (LPS). Therefore, pathogen-mediated activation of host pattern recognition receptors via LPS, and the host cytokine response to infection, serve to induce circulating levels of G-CSF[3]. |
| 贮存 |
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- Recombinant Human Fibroblast Growth Factor 4
- Recombinant Human Granulocyte Colony Stimulating Factor
- Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor(CHO-expressed)
- Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor
- Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor(P.pastoris-expressed)
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