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Recombinant Human Interleukin-6
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| 性状 | Recombinant Human Interleukin-6 有效诱导肝细胞合成急性期蛋白，参与炎症反应。
Synonyms rHuIL-6; BSF-2; CDF; Hybridoma growth factor; IFN-beta-2 Species Human Source E. coli Accession P05231 Gene ID 3569 Molecular Weight Approximately 21,000 Da AA Sequence PVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM Biological Activity The ED50 is <0.1 ng/mL as measured by murine 7TD1 cells, corresponding to a specific activity of 5 × 107 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against 20 mM HAc-NaAc, pH 5.0, 150 mM NaAc buffer. Endotoxin Level <1 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Interleukin-6 (rHuIL-6) to 100 µg/mL using ddH2O. Storage & Stability Lyophilized recombinant Human Interleukin-6 (rHuIL-6) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Interleukin-6 (IL-6) is a 26-kD protein released by fibroblasts, T lymphocytes, endothelial cells, monocytes, and keratinocytes during inflammatory responses. IL-6 has pluripotent activities, including the stimulation of the monocytic lineage, the induction of megakaryopoiesis and the hepatic acute phase response, as well as the modulation of T- and B-cell responses. IL-6 is also capable of mediating direct and indirect tumor cell destruction and that it is potentially important for the immunotherapy of cancer[1. Recombinant human interleukin-6 (IL-6/BSF-2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes[2]. |
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