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Recombinant Human Interleukin-4 (CHO-expressed)
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| 性状 | Recombinant Human Interleukin-4 (CHO-expressed) 是一种 CHO 细胞来源的有效的淋巴细胞生长因子，刺激 B 细胞增殖分化，参与炎症反应。
Synonyms rHuIL-4; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra Species Human Source CHO Accession P05112 Gene ID 3565 Molecular Weight Approximately 15 kDa AA Sequence HKCDITLQEI IKTLNSLTEQ KTLCTELTVT DIFAASKNTT EKETFCRAAT VLRQFYSHHE KDTRCLGATA QQFHRHKQLI RFLKRLDRNL WGLAGLNSCP VKEANQSTLE NFLERLKTIM REKYSKCSS Biological Activity The ED50 is <0.25 ng/mL as measured by TF-1 human erythroleukemic cells, corresponding to a specific activity of >4 × 106 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Interleukin-4 (CHO-expressed) (rHuIL-4) to 100 µg/mL using ddH2O or diluted with PBS. Storage & Stability Lyophilized recombinant Human Interleukin-4 (CHO-expressed) (rHuIL-4) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Interleukin-4 (IL-4) is a cytokine that plays an important role in regulating inflammation and immune responses. It induces the differentiation of naïve helper T cells to Th2 cells. This cytokine binds the IL-4 receptor that also binds another cytokine interleukin 13 (IL-13), which may explain the overlapping functions of IL-4 and IL-13. IL-4, originally designated as B-cell growth factor-1 (BSFl), is described in the supernatant of activated EL-4 thymoma cells as a factor that can co-stimulate B-cells activated with submitogenic concentrations of anti-IgM[1]. |
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