Recombinant Mouse Interleukin-7 (CHO-expressed)

英文名:
Cas号:
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Mouse Interleukin-7 (CHO-expressed) 由来自骨髓和胸腺细胞产生,在 B 细胞淋巴细胞生成和 T 细胞稳态中起关键作用。
Synonyms
rMuIL-7; LP-1; pre-B cell factor
Species
Mouse

Source
CHO

Accession
P10168

Gene ID
16196

Molecular Weight
8-28 kDa

AA Sequence
ECHIKDKEGK AYESVLMISI DELDKMTGTD SNCPNNEPNF FRKHVCDDTK EAAFLNRAAR KLKQFLKMNI SEEFNVHLLT VSQGTQTLVN CTSKEEKNVK EQKKNDACFL KRLLREIKTC WNKILKGSIH HHHHH

Biological Activity
The ED50 is <0.4ng/mL as measured by 2E8 cells.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Murine Interleukin-7 (CHO-expressed) (rMuIL-7) to 100 µg/mL using ddH2O or diluted with PBS.

Storage & Stability
Lyophilized recombinant Murine Interleukin-7 (CHO-expressed) (rMuIL-7) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
Interleukin-7 (IL-7) is a nonredundant cytokine produced by nonlymphoid cells that is essential for T-cell development in humans and mice and B-cell development in mice. IL-7 contributes to the maintenance of the size and subset composition of the peripheral T-cell pool by providing growth and survival signals through the IL-7 receptor. The IL-7 receptor has a private α-chain and shares the common γ-chain (γc) with other common cytokine receptor users, such as IL-2, IL-4, IL-15, and IL-21. IL-7 together with these cytokines regulates the expansion and contraction of adaptive immune responses and potentially the memory response to a given antigen. IL-7 modulates memory CD8+ T cells in response to a virus infection and, given in conjunction with adoptive transfer of T cells after herpes simplex virus type 1 infection, improves virus clearance[1].
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