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Recombinant Mouse Interleukin-22

英文名：
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308132605-10 μg 0 ￥4800 请登录
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1308132605-50 μg 0 ￥16200 请登录
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Mouse Interleukin-22 通过保护肠干细胞免受免疫介导的组织损伤从而在上皮再生和抑制慢性炎症反应中起重要作用。
Synonyms
rMuIL-22; Cytokine Zcyto 18; IL-TIF
Species
Mouse

Source
E. coli

Accession
Q9JJY9

Gene ID
50929

Molecular Weight
Approximately 16.8 kDa

AA Sequence
LPVNTRCKLE VSNFQQPYIV NRTFMLAKEA SLADNNTDVR LIGEKLFRGV SAKDQCYLMK QVLNFTLEDV LLPQSDRFQP YMQEVVPFLT KLSNQLSSCH ISGDDQNIQK NVRRLKETVK KLGESGEIKA IGELDLLFMS LRNACV

Biological Activity
The ED50 is <0.5 ng/mL as measured by Colo205 cells.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Murine Interleukin-22 (rMuIL-22) to 100 µg/mL using ddH2O or PBS.

Storage & Stability
Lyophilized recombinant Murine Interleukin-22 (rMuIL-22) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
Interleukin-22 (IL-22) is a member of the IL-10 family of cytokines, expressed predominantly by subsets of innate lymphoid cells (ILCs) and activated T cells, including T helper 1 (TH1) cells, TH17 cells and TH22 cells. IL-22 can be recognized by a heterodimeric receptor complex that consists of two transmembrane subunits: IL-22R1 and IL-10R2. The binding of IL-22 to its receptor activates the JAK/STAT and MAPK signaling pathway, resulting in gene expression or repression. Since the IL-10R2 is shared by five cytokines (IL-10, IL-22, IL-26, IL-28, and IL-29) and is widely expressed in most cells, the expression of the IL-22R1 determines whether a cell is the target of IL-22. IL-22 has a considerable therapeutic potential in graft-versus-host disease (GVHD), which is a frequent and challenging complication following allogeneic stem cell transplantation[1].
贮存
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