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Recombinant Human Interleukin-6 Receptor (CHO-expressed)

英文名：
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308132736-10 μg 0 ￥3900 请登录
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1308132736-50 μg 0 ￥10400 请登录
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Human Interleukin-6 Receptor (CHO-expressed) 负责白细胞介素-6的信号转导，可能与免疫疾病和各种传染病有关。
Synonyms
rHuIL-6R; IL-6RA; IL-6R 1; CD126; Membrane glycoprotein 80 ; 重组人白细胞介素-6受体 (CHO-表达)
Species
Human

Source
CHO

Accession
P08887

Gene ID
3570

Molecular Weight
54-56 kDa

AA Sequence
LAPRRCPAQE VARGVLTSLP GDSVTLTCPG VEPEDNATVH WVLRKPAAGS HPSRWAGMGR RLLLRSVQLH DSGNYSCYRA GRPAGTVHLL VDVPPEEPQL SCFRKSPLSN VVCEWGPRST PSLTTKAVLL VRKFQNSPAE DFQEPCQYSQ ESQKFSCQLA VPEGDSSFYI VSMCVASSVG SKFSKTQTFQ GCGILQPDPP ANITVTAVAR NPRWLSVTWQ DPHSWNSSFY RL

Biological Activity
The ED50 is <0.2 μg/mL as measured by M1 cells.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human Interleukin-6 Receptor (CHO-expressed) (rHuIL-6R) to 100 μg/mL using ddH2O or PBS.

Storage & Stability
Lyophilized recombinant Human Interleukin-6 Receptor (CHO-expressed) (rHuIL-6R) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
The IL-6 receptor–signaling system is made up of two receptor chains and downstream signaling molecules. The IL-6 receptor (IL-6R) constitutes the IL-6-binding chain, which occurs in two forms, 80 kDa transmembrane and 50-55 kDa-soluble IL-6R (sIL-6R), whereas 130 kDa gp130 constitutes the signal-transducing chain. Both of these proteins belong to the cytokine receptor family with a Trp-Ser-X-Trp-Ser motif[1].
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