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Recombinant Human Monocyte Chemotactic Protein-1/CCL2

英文名：
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308132749-10 μg 0 ￥4200 请登录
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1308132749-50 μg 0 ￥10800 请登录
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Human Monocyte Chemotactic Protein-1/CCL2 是属于CC趋化因子家族的细胞因子。
Synonyms
rHuMCP-1/CCL2; C-C motif chemokine 2; MCAF; MCP-1; SCYA2 ; 重组人单核细胞趋化蛋白1
Species
Human

Source
E. coli

Accession
P13500

Gene ID
6347

Molecular Weight
Approximately 8.7 kDa

AA Sequence
QPDAINAPVT CCYNFTNRKISVQR LASYRRITSS KCPKEAVIFK TIVAKEICAD PKQKWVQDSM DHLDKQTQTP KT

Biological Activity
The ED50 is <1 μg/mL as measured by CHO-K1/Gα15/hCCR2 cells (human Gα15 and human CCR2 stably expressed in CHO-K1 cells).

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human Monocyte Chemotactic Protein-1/CCL2 (rHuMCP-1/CCL2) to 100 μg/mL using ddH2O or PBS.

Storage & Stability
Lyophilized recombinant Human Monocyte Chemotactic Protein-1/CCL2 (rHuMCP-1/CCL2) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
CCL2 is produced by a variety of cell types, either constitutively or after induction by oxidative stress, cytokines, or growth factors. CCL2 is produced by many cell types, including endothelial, fibroblasts, epithelial, smooth muscle, mesangial, astrocytic, monocytic, and microglial cells. CCL2 regulates the migration and infiltration of monocytes, memory T lymphocytes, and natural killer (NK) cells[1]. The chemokine CCL2 and its main chemokine receptor CCR2 have been implicated in the pathogenesis of several different disease processes, including vascular permeability and attraction of immune cells during metastasis, a number of different neurological disorders, autoimmune disease, obesity, and atherosclerosis[2].
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