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Recombinant Rat Leptin

英文名：
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308132745-50 μg 0 ￥1800 请登录
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1308132745-100 μg 0 ￥2200 请登录
- +
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Rat Leptin是脂肪细胞分泌的一种激素，通过抑制摄食和增加产热来帮助调节能量平衡。
Synonyms
rRtLeptin; Obesity protein (OB) ; 重组大鼠瘦素
Species
Rat

Source
E. coli

Accession
P50596

Gene ID
25608

Molecular Weight
Approximately 16.3 kDa

AA Sequence
MVPIHKVQDD TKTLIKTIVT RINDISHTQS VSARQRVTGL DFIPGLHPIL SLSKMDQTLA VYQQILTSLP SQNVLQIAHD LENLRDLLHL LAFSKSCSLP QTRGLQKPES LDGVLEASLY STEVVALSRL QGSLQDILQQ LDLSPEC

Biological Activity
The ED50 is <10 μg/mL as measured by LoVo cells, corresponding to a specific activity of >100 units/mg.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against 50 mM Tris, pH 8.0.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Rat Leptin (rRtLeptin) to 100 μg/mL using ddH2O.

Storage & Stability
Lyophilized recombinant Rat Leptin (rRtLeptin) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
A sensor (leptin production by adipose cells) monitors the size of the adipose tissue mass. Hypothalamic centers receive and integrate the intensity of the leptin signal through leptin receptors (LRb). Effector systems, including the sympathetic nervous system, control the two main determinants of energy balance-energy intake and energy expenditure[1]. Recessive mutations in the leptingene are associated with massive obesity in mice and humans, establishing a genetic basis for obesity. Leptin circulates in blood and acts on the brain to regulate food intake and energy expenditure. When fat mass falls, plasma leptin levels fall, stimulating appetite and suppressing energy expenditure until fat mass is restored. When fat mass increases, leptin levels increase, suppressing appetite until weight is lost. This system maintains homeostatic control of adipose tissue mass[2].
贮存
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