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Recombinant Human TRAIL/Apo2L
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| 性状 | Recombinant Human TRAIL/Apo2L 是一种作为配体的蛋白，通过死亡受体参与诱导细胞凋亡。
Synonyms rHuTRAIL/Apo2L; TNFSF10; CD253 ; 重组人肿瘤坏死因子凋亡诱导配体 Species Human Source E. coli Accession P50591 Gene ID 8743 Molecular Weight Approximately 19.6 kDa AA Sequence MVRERGPQRV AAHITGTRGR SNTLSSPNSK NEKALGRKIN SWESSRSGHS FLSNLHLRNG ELVIHEKGFY YIYSQTYFRF QEEIKENTKN DKQMVQYIYK YTSYPDPILL MKSARNSCWS KDAEYGLYSI YQGGIFELKE NDRIFVSVTN EHLIDMDHEA SFFGAFLVG Biological Activity The ED50 is <40 ng/mL as measured by RPMI-8226 cells, corresponding to a specific activity of >2.5 × 104 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human TRAIL/Apo2L (rHuTRAIL/Apo2L) to 100 μg/mL using ddH2O or PBS. Storage & Stability Lyophilized recombinant Human TRAIL/Apo2L (rHuTRAIL/Apo2L) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Apo2L/TRAIL is one of several members of the TNF gene superfamily that induce apoptosis through engagement of death receptors[1]. TRAIL and its receptors have been used as the targets of several anti-cancer therapeutic. TRAIL has also been implicated as a pathogenic or protective factor in various pulmonary diseases, particularly pulmonary arterial hypertension[2]. |
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