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Recombinant Human Tumor Necrosis Factor type I (CHO-expressed)
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| 性状 | Recombinant Human Tumor Necrosis Factor type I (CHO-expressed) 是一种参与全身炎症反应的细胞因子，是构成急性时相反应的细胞因子之一。
Synonyms rHuTNFRI; TNFRSF1A; TNFAR; CD120a ; 重组人肿瘤坏死因子 α (CHO 细胞表达) Species Human Source CHO Accession P19438 Gene ID 7132 Molecular Weight 28-35 kDa AA Sequence DSVCPQGKYI HPQNNSICCT KCHKGTYLYN DCPGPGQDTD CRECESGSFT ASENHLRHCL SCSKCRKEMG QVEISSCTVD RDTVCGCRKN QYRHYWSENL FQCFNCSLCL NGTVHLSCQE KQNTVCTCHA GFFLRENECV SCSNCKKSLE CTKLCLPQIE N Biological Activity The ED50 is <50 ng/mL as measured by 929 cells. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Tumor Necrosis Factor type I (CHO-expressed) (rHuTNFRI) to 100 μg/mL using ddH2O or PBS. Storage & Stability Lyophilized recombinant Human Tumor Necrosis Factor type I (CHO-expressed) (rHuTNFRI) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background TNF-α (Tumor Necrosis Factor type I) is a cytokine involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. TNF-α is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. The secreted form of human TNFα takes on a triangular pyramid shape, and weighs around 17-kD. Both the secreted and the membrane bound forms are biologically active, although the specific functions of each is controversial. But, both forms do have overlapping and distinct biological activities[1]. |
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