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Recombinant Mouse Transforming growth factor-beta receptor type 2, His (HEK293-expressed)
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| 性状 | Recombinant Mouse Transforming growth factor-beta receptor type 2, His 由带有 His 标签的 C 端蛋白激酶域和 N 端胞外域组成。TGF-beta receptor type-2 是TGF-β 家族所有成员的配体结合受体。
Synonyms TGFR-2; TGF-beta type II receptor; TGF-beta receptor type 2; TbetaR-II Species Mouse Source HEK 293 Accession Q62312-2 Gene ID 21813 Molecular Weight 25-38 kDa AA Sequence IPPHVPKSVN SDVMASDNGG AVKLPQLCKF CDVRLSTCDN QKSCMSNCSI TAICEKPHEV CVAVWRKNDK NITLETVCHD PKLTYHGFTL EDAASPKCVM KEKKRAGETF FMCACNMEEC NDYIIFSEEY TTSSPDHHHH HH Biological Activity Data is not available. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS, pH 7.4. Endotoxin Level <1 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Mouse Transforming growth factor-beta receptor type 2, His (HEK293-expressed) (rMuTGF-beta receptor 2, His) to 100 µg/mL using ddH2O or diluted with PBS. Storage & Stability Lyophilized recombinant Mouse Transforming growth factor-beta receptor type 2, His (HEK293-expressed) (rMuTGF-beta receptor 2, His) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Transforming growth factor-beta (TGF-β) is a pleiotropic cytokine with the capability to act as tumor suppressor or tumor promoter depending on the cellular context. TGF-beta receptor type-2 (TGFBR2) is the ligand-binding receptor for all members of the TGF-βfamily and expressed in virtually all cell types including fibroblasts. Regulation of tumor-stromal cross-talk through fibroblastic TGF-βpathway may depend on fibroblast phenotype, emphasising the importance to characterise tumor microenvironment subtypes[1]. |
| 贮存 |
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