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Recombinant Human AG-3, His (HEK293-expressed)

英文名：
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308132987-10 μg 0 ￥3200 请登录
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1308132987-50 μg 0 ￥9800 请登录
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Human AG-3, His (HEK293-expressed) 是带有 N 末端 His 标签的人重组 AG-3，在 HEK293 细胞中表达。
Synonyms
rHuAG-3, His; HAG-3; AGR3; AG3 ; 重组人 AG-3，His (HEK293 细胞表达)
Species
Human

Source
HEK 293

Accession
Q8TD06

Gene ID
155465

Molecular Weight
Approximately 16.0 kDa

AA Sequence
IAIKKEKRPP QTLSRGWGDD ITWVQTYEEG LFYAQKSKKP LMVIHHLEDC QYSQALKKVF AQNEEIQEMA QNKFIMLNLM HETTDKNLSP DGQYVPRIMF VDPSLTVRAD IAGRYSNRLY TYEPRDLPLL IENMKKALRL IQSELHHHHH H

Biological Activity
Data is not available.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against 20 mM Tris-HCl, 150 mM NaCl, 2 mM EDTA, pH 8.5.

Endotoxin Level
<1 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human AG-3, His (HEK293-expressed) (rHuAG-3, His) to 100 µg/mL using ddH2O or diluted with PBS.

Storage & Stability
Lyophilized recombinant Human AG-3, His (HEK293-expressed) (rHuAG-3, His) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
AG-3 (Anterior gradient 3; AGR3), a member of the protein disulfide isomerase (PDI) family, shares high sequence homology with AG-2. AG-3 is overexpressed in breast, prostate and ovarian cancer. Combined AG-3 and acid mucopolysaccharides could serve as a diagnostic marker for well-differentiated intrahepatic cholangiocarcinoma. AG-3 expression was correlated with the level of differentiation in the serous type of ovarian cancer. AGR3 activates Wnt/β-catenin signalling and promotes the nuclear translocation of β-catenin to upregulate stemness related genes[1].
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