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Recombinant Human Aldo-keto Reductase 1C4, His
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| 性状 | Recombinant Human Aldo-keto Reductase 1C4, His 是具有N端His标签的人重组 AKR1C4，来源于大肠杆菌，对应于人 AKR1C4 的氨基酸 1-323。
Synonyms rHuAldo-keto Reductase 1C4, His; AKR-1C4; Aldo-keto Reductase 1C4 ; 重组人类醛酮还原酶 1C4，His Species Human Source E. coli Accession P17516 Gene ID 1109 Molecular Weight Approximately 38.0 kDa AA Sequence HHHHHHMDPK YQRVELNDGH FMPVLGFGTY APPEVPRNRA VEVTKLAIEA GFRHIDSAYL YNNEEQVGLA IRSKIADGSV KREDIFYTSK LWCTFFQPQM VQPALESSLK KLQLDYVDLY LLHFPMALKP GETPLPKDEN GKVIFDTVDL SATWEVMEKC KDAGLAKSIG VSNFNCRQLE MILNKPGLKY KPVCNQVECH PYLNQSKLLD FCKSKDIVLV AHSALGTQRH KLWVDPNSPV LLEDPVLCAL AKKHKQTPAL IALRYQLQRG VVVLAKSYNE QRIRENIQVF EFQLTSEDMK VLDGLNRNYR YVVMDFLMDH PDYPFSDEY Biological Activity Data is not available. Appearance Solution Formulation Supplied as a 0.2 μm filter solution of 20 mM Tris, 150 mM NaCl, pH 8.0. Endotoxin Level <1 EU/μg, determined by LAL method. Reconstitution N/A Storage & Stability Recombinant Human Aldo-keto Reductase 1C4, His (rHuAldo-keto Reductase 1C4, His) is stored at -20°C. It is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Shipping with dry ice. Background Aldo-keto Reductase 1C4 (AKR1C4) is a member of the aldo-keto reductase (AKR) superfamily. AKR1C4 catalyzes the reversible oxidoreduction of various 3α-hydroxysteroids and prostaglandins as well as the oxidation of trans‑dihydrodiols of aromatic hydrocarbons and alicyclic alcohols. AKR1C4 acts as NADPH-dependent 3-, 17- and 20-ketosteroid reductases and as 3α-, 17β- and 20α-hydroxysteroid oxidases. AKR1C4 reduces 11-ketodihydrotestosterone (11KDHT) to both 3α- and 3β-hydroxy metabolites. AKR1C4 is important for steroid hormone metabolism primarily through synthesis and clearance of testosterone. AKR1C4 is virtually liver-specific and its high Kcat/Km allows this enzyme to form 5α/5β-tetrahydrosteroids robustly[1][2]. |
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