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14-3-3 sigma (SFN)
英文名：Rabbit Monoclonal Antibody
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检测信息查询
| 货号 | 规格 | 货期 | 库存 | 价格 | 会员价 | 订购 |
| 1308113288-100ul | 现货 | 0 | ￥0 | 请登录 |
| 别 名 | SFN antibody, YWHAS antibody, 14-3-3 protein sigma antibody, Epithelial cell marker protein 1 antibody, Stratifin antibody |
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| 产品参数 | 【产品介绍】14-3-3 proteins are composed of a
highly conserved multigene family of small acidic proteins. Responsive to DNA damage, 14-3-3 sigma expression is induced in a p53-dependent manner. 14-3-3 sigma sequesters cyclin B1-CDC2 complex in cytoplasm, and prevents its entry into nucleus resulting in G2/M cell cycle arrest. Furthermore, 14-3-3 sigma can link to CDK2 and CDK4 and block the cell cycle entry. Thus, 14-3-3 sigma acts as a negative regulator of cell cycle progression and is linked to cancer (1). A keratinocyte-releasable form of 14-3-3 sigma is a potent MMP-1-stimulatory factor in dermal fibroblasts. When it is released from keratinocytes, it induces the expression of MMP1, MMP3, MMP8 and MMP24 in fibroblasts through the p38 mitogen-activated protein kinase (MAPK) signaling pathway (2). Recommended Applications WB Applications and Recommended Dilution Factors WB: 1:1,000 - 10,000 Species Reactivity * Human, Mouse, Rat *Species cross-reactivity is based on WB analysis. Western blot analysis on (A) fetal lung, (B) A549, (C) human kidney, and (D) human spleen lysates using anti-14-3-3 sigma RabMAb (cat. #5209-1). Specificity A synthetic peptide corresponding to residues in human 14-3-3 sigma was used as an immunogen. |
| 性状 | 【反应特异性】Human , Mouse , Rat
【克隆 ID】EPR5872 【用途】WB 【抗原分子量】28kDa |
| 贮存 | Storage Condition and Buffer Store at -20 °C. Antibody buffer, 0.01% sodium azide, 50% Glycerol and 0.05% BSA. Stable for 12 months from date of receipt |
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