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4-1BBL (TNFSF9)
英文名：Rabbit Monoclonal Antibody
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检测信息查询
| 货号 | 规格 | 货期 | 库存 | 价格 | 会员价 | 订购 |
| 1308113292-100ul | 现货 | 0 | ￥0 | 请登录 |
| 别 名 | TNFSF9 antibody, 4-1BB-L antibody, CD137L antibody, Tumor necrosis factor ligand superfamily member 9 antibody, 4-1BB ligand antibody |
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| 产品参数 | 【产品介绍】4-1BB was originally described as
a cDNA expressed by activated murine T cells and subsequently demonstrated to encode a member of the tumor necrosis factor receptor family of integral membrane proteins. Recently, a murine ligand for 4-1BB (mu4-1BB-L) was cloned and demonstrated to be a member of an emerging family of ligands with structural homology to tumor necrosis factor. Both monoclonal antibody to hu4-1BB and cells transfected with hu4-1BB-L induced a strong proliferative response in mitogen co-stimulated primary T cells. In contrast, ligation of 4-1BB on T cell clones enhanced activation-induced cell death when triggered by engagement of the TCR/CD3 complex. (1). To reject tumors, T cells must overcome poor tumor immunogenicity and an adverse tumor microenvironment. It has been shown that primary human T cells expressing CD80 and 4-1BBL vigorously respond to tumor cells lacking costimulatory ligands and provoke potent rejection of large, systemic tumors in immunodeficient mice (2). Recommended Applications WB, IHC, ICC, IP Applications and Recommended Dilution Factors WB: 1:500 IHC: 1:100 ICC: 1:100 IP: 1:40 Species Reactivity * Human *Cross reactivity determined by western blot only. Specificity A synthetic peptide corresponding to residues near the N-terminus of human 4-1BBL was used as an immunogen. |
| 性状 | 【反应特异性】Human
【克隆 ID】EPR1172Y 【用途】WB , IHC , ICC , IP 【抗原分子量】26kDa |
| 贮存 | Storage Condition and Buffer Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
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