B7-H2 (ICOSLG)

英文名:Rabbit Monoclonal Antibody
Cas号:
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别 名 ICOSLG antibody, B7-H2 antibody, B7H2 antibody, B7RP-1 antibody, B7RP1 antibody, CD275 antibody, GL50 antibody, ICOS-L antibody, ICOSL antibody, KIAA0653 antibody, LICOS antibody, ICOS ligand antibody, B7-like protein Gl50 antibody, B7-related protein 1 a
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】B7-H2, or Inducible costimulator ligand
(ICOSL), is a member of the Ig superfamily and belongs
to the B7 family of costimulatory molecules. It
specifically binds to ICOS, but not to other T
cell costimulatory molecules such as CD28 and
CTLA-4. B7-H2-ICOS interaction appears to be very
important in the expansion of activated T cells
and late-phase immune responses (1). B7-H2 enhances
the proliferation of both CD4 and CD8 T cells, the
secretion of Th1- and/or Th2-type cytokines, and
the expression of CD154 (CD40 ligand) on T cells (2). It
is expressed constitutively on B lymphocytes and at
low levels on monocytes (3). Furthermore,
B7-H2-ICOS interaction induces IL-10 production, which
plays an important role in reducing immune responses (4).


Recommended Applications

WB, ICC
Applications and Recommended Dilution Factors

WB: 1:1,000 - 10,000
ICC: 1:50 - 100
Species Reactivity *

Human

*Species cross-reactivity is based on WB analysis.

Products Data
Western blot analysis on (A) HL-60, (B) HuT78, (C)
HUVEC treated with TNF-alpha, and (D) HUVEC cell
lysates using anti-B7-H2 RabMAb (cat. #5329-1).

Specificity

A synthetic peptide corresponding to residues in
the intracellular domain of human B7-H2 was used as
an immunogen.
性状 【反应特异性】Human
【克隆 ID】EPR6071
【用途】WB , ICC
【抗原分子量】63 - 72kDa
贮存 Storage Condition and Buffer Store at -20 °C. Antibody buffer, 0.01% sodium azide, 50% Glycerol and 0.05% BSA. Stable for 12 months from date of receipt
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