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Beclin-1
英文名：Rabbit Monoclonal IgG
Cas号：
Cas号：
检测信息查询
| 货号 | 规格 | 货期 | 库存 | 价格 | 会员价 | 订购 |
| 1308113364-100ul | 现货 | 0 | ￥0 | 请登录 |
| 别 名 | Coiled-coil myosin-like BCL2-interacting protein, Protein GT197 |
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| 产品参数 | 【产品介绍】The Beclin-1 (BECN1) gene encodes a
60-kDa coiled-coil protein that interacts with the prototypic apoptosis inhibit o r Bcl-2 (1). Beclin-1 promotes autophagy in autophagy-defective yeast with a targeted disruption of agp6/vps30, a n d in human MCF7 breast carcinoma cells. The autophagy-promoting activity of Beclin-1 in MCF7 cells is associated with inhibition of MCF7 cellular proliferation, in vitro clonigenicity a n d tum o r igenesis. Endogenous Beclin-1 protein expression is frequently low in human breast epithelial carcinoma cell lines a n d tissue, but is expressed ubiquitously at high levels in n o r mal breast epithelia (2). It has also been shown that Beclin 1 contains a leucine-rich nuclear exp o r t signal motif raising the possibility that its autophagy a n d / o r tum o r suppress o r function may require regulated, CRM1-dependent, nucleocytoplasmic transp o r t (3). WB: 1:5000 IHC: 1:50 ICC: 1:50 100 IP: 1:50 A. Western blot analysis on A431 cell lysate using anti-Beclin-1 RabMAb (cat. # 2026-1), dilution 1:5000. B. Immunohistochemical staining of paraffin-embedded human breast tissue using anti-Beclin-1 RabMAb (cat. #2026-1). |
| 性状 | 【反应特异性】Human
【克隆 ID】EPR1733Y 【用途】WB , IHC , ICC , IP 【抗原分子量】52 kDa |
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