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Calpain 2 (large subunit) (CAPN2)
英文名：Rabbit Monoclonal Antibody
Cas号：
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检测信息查询
| 货号 | 规格 | 货期 | 库存 | 价格 | 会员价 | 订购 |
| 1308113390-100ul | 现货 | 0 | ￥0 | 请登录 |
| 别 名 | CAPN2 antibody, CANP2 antibody, CANPL2 antibody, CANPml antibody, FLJ39928 antibody, mCANP antibody, Calpain-2 catalytic subunit antibody, Calpain M-type antibody, Calpain large polypeptide L2 antibody, Calpain-2 large subunit antibody, Millimolar-calpain |
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| 产品参数 | 【产品介绍】The calcium-activated protease calpain cleaves
a variety of biologically important proteins and serves, therefore, as a key regulator of many cellular functions. Activation of both main isoforms, calpain 1 and calpain 2, was demonstrated previously in Alzheimer's disease. Calpain 2 could be directly involved in tau hyperphosphorylation by modulating protein kinase activities. Results provide evidence of the important role of the calpain proteolytic system in the pathogenesis of neurodegenerative diseases with tau neurofibrillary pathology (1). Calpain is intimately involved in modulating cell adhesion and migration. The two ubiquitous isoforms of this protease, calpain I and II, are considered to be cytosolic proteins that can translocate to both focal complexes/adhesions or the plasma membrane. Results reveal an increased association of calpain I, II, calpastatin, and the 30-kDa regulatory subunit with the endoplasmic reticulum and Golgi apparatus as evidenced by their position in the gradient relative to calnexin, Rab6, caveolin, and beta1 integrin after laminin stimulation. Further experiments established that calpain II colocalizes with phosphatidylinositol 4,5-bisphosphate (2). Recommended Applications WB Applications and Recommended Dilution Factors WB: 1:1,000 - 10,000 Species Reactivity * Human, Mouse, Rat *Species cross-reactivity is based on WB analysis. Products Data Western blot analysis on (A) PC-3, (B) HeLa, (C) A431, and (D) 293T cell lysates using anti-Calpain 2 (large subunit) RabMAb (cat. #5511-1). Specificity A synthetic peptide corresponding to residues in human Calpain 2 (large subunit) was used as an immunogen. |
| 性状 | 【反应特异性】Human , Mouse , Rat
【克隆 ID】EPR5977 【用途】WB 【抗原分子量】80kDa |
| 贮存 | Storage Condition and Buffer Store at -20° C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt. |
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