本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的，不可用于人类或动物的临床诊断或者治疗，非药用，非食用。
CaMKII Phospho (pT286) (CAMK2A)
英文名：Rabbit Monoclonal Antibody
Cas号：
Cas号：
检测信息查询
| 货号 | 规格 | 货期 | 库存 | 价格 | 会员价 | 订购 |
| 1308113392-100ul | 现货 | 0 | ￥0 | 请登录 |
| 别 名 | CAMK2A antibody, CAMKA antibody, KIAA0968 antibody, Calcium/calmodulin-dependent protein kinase type II subunit alpha antibody, antibody |
| Cas号 | |
| M D L | |
| 分子式 | |
| 分子量 | |
| 产品参数 | 【产品介绍】Calcium/calmodulin-dependent protein kinase
II (CaMKII) is a widely distributed protein kinase that regulates numerous physiological functions. It is a ubiquitous serine/threonine protein kinase which is abundant in brain as a major PSD constituent. This enzyme is composed of distinct but related subunits (alpha, beta, gamma, and delta) (1). The synapse contains densely localized and interacting proteins that enable it to adapt to changing inputs. A Ca2+-sensitive protein complex involved in the regulation of AMPA receptor synaptic plasticity. The complex is comprised of MUPPI, a multi-PDZ domain-containing protein; SynGAP, a synaptic GTPase-activating protein; and the Ca2+/calmodulin-dependent kinase CaMKII. In synapses of hippocampal neurons, SynGAP and CaMKII are brought together by direct physical interaction with the PDZ domains of MUPP1, and in this complex, SynGAP is phosphorylated. Ca2+CaM binding to CaMKII dissociates it from the MUPP1 complex, and Ca2+ entering via the NMDAR drives the dephosphorylation of SynGAP (2). The most important autophosphorylation site is Threonine 286, which resides in the vicinity of the autoinhibitory domain (3). Recommended Applications WB Applications and Recommended Dilution Factors WB: 1:1,000 - 10,000 Species Reactivity * Human, Mouse, Rat *Species cross-reactivity is based on WB analysis Products Data Western blot analysis on rat brain lysates using anti-Phospho-CaMKII (pT286) RabMAb (cat. #3891-1). Cells were either (A) untreated (B) treated with Lambda Phosphatase. Specificity A phospho specific peptide corresponding to residues surrounding Threonine 286 of human CaMKII was used as an immunogen. This antibody only detects CaMKII phosphorylated at Threonine 286. |
| 性状 | 【反应特异性】Human , Mouse , Rat
【克隆 ID】EPR1830 【用途】WB 【抗原分子量】45 - 70kDa |
| 贮存 | Storage Condition and Buffer Store at -20° C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
沪公网安备 31012002003054号