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Chk1 (CHEK1)
英文名：Rabbit Monoclonal Antibody
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检测信息查询
| 货号 | 规格 | 货期 | 库存 | 价格 | 会员价 | 订购 |
| 1308113449-100ul | 现货 | 0 | ￥0 | 请登录 |
| 别 名 | CHEK1 antibody, CHK1 antibody, Serine/threonine-protein kinase Chk1 antibody, antibody |
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| 产品参数 | 【产品介绍】Chk1 is a serine/threonine-protein
kinase required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA (1). It is regulated by Atr and plays an important role in embryonic development and tumor suppression (2). The activated Chk1 triggers the G2/M checkpoint, which arrests the cells in G2 to allow them to repair their DNA (3). The inhibition of Chk1 kinase results in the abrogation of the G2/M checkpoint and leads to cell death (3). Chk1 is activated in response to replication blocks and genotoxic stress, via phosphorylation of serines 317 and 345 (4). Activated Chk1 can bind to, phosphorylate (at serine 216), and inactivate cdc25c (4, 5). Recommended Applications WB Applications and Recommended Dilution Factors WB: 1:1,000 - 10,000 Species Reactivity Human Products Data Western blot analysis on (A) Jurkat (B) K562, (C) MCF-7, and (D) HepG52 cell lysates using anti-Chk1 RabMAb (cat. # 2865-1). Specificity A synthetic peptide corresponding to residues in human Chk1 was used as an immunogen. |
| 性状 | 【反应特异性】Human
【克隆 ID】EPR3952 【用途】WB 【抗原分子量】56kDa |
| 贮存 | Storage Condition and Buffer Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
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