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Chk2 (CHEK2)
英文名：Rabbit Monoclonal Antibody
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检测信息查询
| 货号 | 规格 | 货期 | 库存 | 价格 | 会员价 | 订购 |
| 1308113450-100ul | 现货 | 0 | ￥0 | 请登录 |
| 别 名 | CHEK2 antibody, CDS1 antibody, CHK2 antibody, HuCds1 antibody, LFS2 antibody, PP1425 antibody, RAD53 antibody, Serine/threonine-protein kinase Chk2 antibody, Cds1 antibody |
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| 产品参数 | 【产品介绍】Chk2 is a cell cycle checkpoint regulator
and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, Chk2 is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in Chk2 have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this protein are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors (1). Recommended Applications WB Applications and Recommended Dilution Factors WB: 1:10,000 - 50,000 Species Reactivity * Human *Cross reactivity determined by western blot only. Products Data Western blot analysis on (A) SH-SY5Y, (B) HeLa, (C) HT-29, and (D) 293T cell lysates using anti-Chk2 RabMAb (cat. #3899-1). Specificity A synthetic peptide corresponding to residues at the N-terminus of human Chk2 was used as an immunogen. |
| 性状 | 【反应特异性】Human
【克隆 ID】EPR5528 【用途】WB 【抗原分子量】62kDa |
| 贮存 | Storage Condition and Buffer Store at -20° C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
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