CSN7A (COPS7A)

英文名:Rabbit Monoclonal Antibody
Cas号:
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别 名 COPS7A antibody, CSN7A antibody, MGC110877 antibody, COP9 signalosome complex subunit 7a antibody, Dermal papilla-derived protein 10 antibody, JAB1-containing signalosome subunit 7a antibody
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】CSN7A is a component of the COP9
signalosome complex (CSN), a complex involved in
various cellular and developmental processes. The
CSN complex is an essential regulator of the ubiquitin
(Ubl) conjugation pathway by mediating the deneddylation
of the cullin subunits of SCF-type E3 ligase
complexes, leading to decrease the Ubl ligase activity
of SCF-type complexes such as SCF, CSA or DDB2 (1).
CSN7A and PMF-1 bind to each other, as well as compete
with each other for binding to Nrf-2. This competition
for Nrf-2 binding and interaction with each other
is implicated in the regulation of SSAT transcription (2).


Recommended Applications

WB
Applications and Recommended Dilution Factors

WB: 1:1,000 - 10,000
Species Reactivity *

Human, Rat

*Species cross-reactivity is based on WB analysis.

Products Data

Western blot analysis on (A) HeLa, (B) JAR, (C)
fetal muscle, (D) human brain, (E) human heart,
and (F) human kidney lysates using anti-CSN7A RabMAb
(cat. #5213-1).

Specificity

A synthetic peptide corresponding to residues in human CSN7A was used as an immunogen.
性状 【反应特异性】Human , Rat
【克隆 ID】EPR6463
【用途】WB
【抗原分子量】30kDa
贮存 Storage Condition and Buffer Store at -20 °C. Antibody buffer, 0.01% sodium azide, 50% Glycerol and 0.05% BSA. Stable for 12 months from date of receipt
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