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Cytokeratin 8
英文名：Rabbit Monoclonal IgG
Cas号：
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检测信息查询
| 货号 | 规格 | 货期 | 库存 | 价格 | 会员价 | 订购 |
| 1308113493-100ul | 现货 | 0 | ￥0 | 请登录 |
| 别 名 | Cytokeratin-8, CK-8, Keratin-8, K8 |
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| 产品参数 | 【产品介绍】Keratins, the intermediate filament proteins
of epithelial cells, connect to desmosomes, the cell-cell adhesion structures at the surface membrane. Among the various intermediate filament (IF) proteins, cytokeratin 8 (CK8) is especially remarkable as it is produced early in embryogenesis, is the only type-II CK occurring in many simple epithelial cells, a n d can also be synthesized in certain non-epithelial cells (1). Keratin 8 a n d 18 (CK8/18) are the maj o r keratin pair in simple-type epithelia, as found in the liver, pancreas, a n d intestine (2). While K8/K18 are essential f o r maintaining structural integrity, there is accumulating evidence indicating that they also exert non-mechanical functions. It has been rep o r ted that K8/K18-free hepatocytes from K8-null mice are m o r e sensitive to Fas-mediated apoptosis, in line with an increased Fas density at the cell surface a n d an altered c-Flip regulation of the anti-apoptotic ERK1/2 signaling pathway (3). WB: 1:25,000 50,000 IHC: 1:250 500 ICC: 1:100 250 Flow Cytometry: 1:20 IP: 1:70 A. Western blot analysis on A431 cell lysate using anti-CK8 RabMAb(cat. # 2032-1), dilution 1:50,000. B. Immunohistochemical analysis of paraffin-embedded human breast adenocarcinoma using anti-CK8 RabMAb (cat. #2032-1). |
| 性状 | 【反应特异性】Human
【克隆 ID】EP1628Y 【用途】WB , IHC , ICC , FC , IP 【抗原分子量】52 kDa |
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