DDIT4 / REDD-1

英文名:Rabbit Monoclonal Antibody
Cas号:
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别 名 DDIT4 antibody, Dig2 antibody, FLJ20500 antibody, REDD-1 antibody, REDD1 antibody, RP11-442H21.1 antibody, RTP801 antibody, DNA damage-inducible transcript 4 protein antibody, HIF-1 responsive protein RTP801 antibody, Protein regulated in development and
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】DDIT4 / REDD-1 is a transcriptional target
of p53 induced following DNA damage. It functions in
the regulation of reactive oxygen species (ROS), which
is involved in p63-mediated regulation of
epithelial differentiation (1). DDIT4 / REDD-1 inhibits
mTOR kinase activity in non-muscle and muscle
cells downstream of Akt/PKB and upstream of TSC2. As
a stress responsive negative regulator of mTOR signaling,
it is implicated in controlling skeletal muscle size
(2). Studies show either a pro- or an anti-apoptotic
role during the stress response, depending on the
cell context (3). Furthermore, DDIT4 / REDD-1 is
essential for hypoxia regulation of TORC1 activity (4).


Recommended Applications

WB, ICC
Applications and Recommended Dilution Factors

WB: 1:1,000 - 10,000
ICC: 1:100 - 250
Species Reactivity *

Human, Mouse, Rat

*Species cross-reactivity is based on WB analysis.

Products Data

Western blot analysis on (A) Jurkat, (B) 293T, and
(C) K562 cell lysates using anti-DDIT4 / REDD-1 RabMAb
(cat. #5144-1).

Specificity

A synthetic peptide corresponding to residues in human
DDIT4 / REDD-1 was used as an immunogen.
性状 【反应特异性】Human , Mouse , Rat
【克隆 ID】EPR4037(2)
【用途】WB , ICC
【抗原分子量】35kDa
贮存 Storage Condition and Buffer Store at -20 °C. Antibody buffer, 0.01% sodium azide, 50% Glycerol and 0.05% BSA. Stable for 12 months from date of receipt
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