【产品介绍】Dishevelled 2 is a member of the
dishevelled (dsh) protein family. The vertebrate
dsh proteins have approximately 40% amino acid
sequence similarity with Drosophila dsh. Dishevelled 2 is
a 90-kDa protein that undergoes
posttranslational phosphorylation to form a
95-kDa cytoplasmic protein, which may play a role in
the signal transduction pathway mediated by multiple
Wnt proteins. The mechanisms of dishevelled function in
Wnt signaling are likely to be conserved among metazoans (1).
Recommended Applications
WB
Applications and Recommended Dilution Factors WB: 1:1,000 - 10,000
Species Reactivity * Human, Mouse *Species cross-reactivity is based on WB analysis. Products Data Western blot analysis on F9 cell lysate using
anti-Phospho-Dishevelled 2 (pS143) RabMAb
(cat. #5248-1). Cells were either (A) untreated
or (B) treated with Alkaline Phosphatase. Specificity A phospho specific peptide corresponding to
residues surrounding Serine 143 of human Dishevelled 2
was used as an immunogen. This antibody only
detects Dishevelled 2 phosphorylated at Serine 143. |
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