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FMO3
英文名：Rabbit Monoclonal Antibody
Cas号：
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检测信息查询
| 货号 | 规格 | 货期 | 库存 | 价格 | 会员价 | 订购 |
| 1308113598-100ul | 现货 | 0 | ￥0 | 请登录 |
| 别 名 | FMO3 antibody, FMOII antibody, MGC34400 antibody, TMAU antibody, dJ127D3.1 antibody, Dimethylaniline monooxygenase [N-oxide-forming] 3 antibody, Dimethylaniline oxidase 3 antibody, FMO II antibody, FMO form 2 antibody, Hepatic flavin-containing monooxygen |
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| 产品参数 | 【产品介绍】Flavin-containing monooxygenases (FMO) are
an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous- containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO family is composed of 5 proteins. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of FMO3, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Mutations in FMO3 cause the disorder trimethylaminuria (TMAu), which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non-odorous trimethylamine N-oxide (1). Recommended Applications WB, IHC Applications and Recommended Dilution Factors WB: 1:1,000 - 10,000 IHC: 1:500 - 1000 Species Reactivity * Human, Mouse, Rat *Species cross-reactivity is based on WB analysis. Products Data Western blot analysis on (A) fetal liver and (B) fetal kidney lysates using anti-FMO3 RabMAb (cat. #5526-1). Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-FMO3 RabMAb (cat.# 5526-1). Specificity A synthetic peptide corresponding to residues in human FMO3 was used as an immunogen. |
| 性状 | 【反应特异性】Human , Mouse , Rat
【克隆 ID】EPR6968 【用途】WB , IHC 【抗原分子量】56kDa |
| 贮存 | Storage Condition and Buffer Store at -20° C. Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt. |
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