【产品介绍】IRF-4 belongs to the IRF (interferon
regulatory factor) family of transcription
factors, characterized by an unique tryptophan pentad
repeat DNA-binding domain. The IRFs are important in
the regulation of interferons in response to infection
by viruses and the regulation of interferon-
inducible proteins.IRF-4 is lymphocyte specific
and negatively regulates Toll-like-receptor (TLR)
signaling that is central to the activation of innate
and adaptive immune systems. A mutation in IRF-4 may be
a cause of multiple myeloma (1).Recommended Applications
WB, IHC, ICC, IP, FC
Applications and Recommended Dilution Factors
WB: 1:10,000 - 50,000
IHC: 1:250 - 500
ICC: 1:250 - 500
IP: 1:100 - 500
FC: 1:10 - 100
Species Reactivity *
Human
*Species cross-reactivity is based on WB analysis. Products Data Western blot analysis on (A) Namalwa, (B) HuT-78, and
(C) IM-9 cell lysates using anti-IRF-4 RabMAb (cat. #5391-1). Immunohistochemical analysis of paraffin-embedded
human lymphoma tissue using anti-IRF-4 RabMAb (cat. #5391-1). Immunohistochemical analysis of paraffin-embedded
human tonsil tissue using anti-IRF-4 RabMAb (cat. #5391-1). Specificity
A synthetic peptide corresponding to residues in human
IRF-4 was used as an immunogen. |
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