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IRS-1 Antibody
英文名：IRS-1 Antibody
Cas号：
Cas号：
检测信息查询
| 货号 | 规格 | 货期 | 库存 | 价格 | 会员价 | 订购 |
| 1308114460-100ul | 现货 | 0 | ￥0 | 请登录 |
| 别 名 | IRS-1 |
| Cas号 | |
| M D L | |
| 分子式 | |
| 分子量 | |
| 产品参数 | 【产品介绍】Insulin recept o r substrates (IRS), the
maj o r intracellular substrates of the insulin recept o r (IR), are adapt o r proteins that transduce signals from the IR to downstream effect o r s that are imp o r tant f o r the biological effect of insulin (1-2). After insulin stimulation, IRS proteins are rapidly phosph o r ylated on multiple tyrosine residues. Once phosph o r ylated, IRS proteins bind a n d activate Grb-2, SHP2 a n d the PI3-K p85 subunit (2-3). IRS-1 functions as one of the key regulat o r s of IR a n d the insulin-like growth fact o r -1 recept o r . Disruption of IRS-1 causes growth retardation a n d insulin resistance associated with hypertension, hypertriglyceridemia, a n d impaired endothelium-dependent vascular relaxation (4-5) WB: 1:1,000 IHC: 1:50-100 ICC: 1:250-500 IP: 1:50 A. Western blot analysis on Hela cell lysate using anti-IRS-1 RabMAb (cat. # 1692-1), dilution 1:1,000. B. Immunohistochemical analysis of paraffin-embedded human breast carcinoma using anti-IRS-1 RabMAb (cat. # 1692-1). |
| 性状 | 【产品类型】Rabbit Monoclonal IgG
【反应特异性】Human 【克隆 ID】EP263Y 【用途】WB , IHC , ICC , IP 【产品性状】 【阳性对照】 【产品浓度】 【细胞定位】 【抗原分子量】170 kDa |
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