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JNK1 (pY185) / JNK2 (pY185) /JNK3 (pY223) Phospho (MAPK10)

英文名：JNK1 (pY185) / JNK2 (pY185) /JNK3 (pY223) Phospho (MAPK10)
Cas号：
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别 名 MAPK10 antibody, FLJ12099 antibody, FLJ33785 antibody, JNK3 antibody, JNK3A antibody, MGC50974 antibody, PRKM10 antibody, p493F12 antibody, p54bSAPK antibody, Mitogen-activated protein kinase 10 antibody, MAP kinase p49 3F12 antibody, Stress-activated pro
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】C-Jun N-terminal kinases (JNK) are
distantly related to mitogen-activated protein
kinases (ERKs) and are activated by dual phosphorylation
on Tyr and Thr. The JNK protein kinase group consists
of three isoforms (JNK1, 2, and 3) and
regulates transcription activity of the AP-1 complex,
and release and regulation of cytochome c (1). JNK
becomes activated in vivo in response to
pro-inflammatory cytokines or cellular stresses. Its
full activation requires the phosphorylation of a
threonine and a tyrosine residue in a Thr-Pro-Tyr
motif, which can be catalysed by the protein kinases
mitogen-activated protein kinase kinase MKK4 and MKK7
(2). Unlike other JNK isoforms, JNK3 is only expressed
in the heart and nervous system. JNK3 has been implicated
in stress-induced neuronal apoptosis (3).

Recommended Applications
WB, IP
Applications and Recommended Dilution Factors
WB: 1:1,000
IP: 1:20
Species Reactivity *
Human, Mouse, Rat
*Cross reactivity determined by western blot only.

Products Data

Western blot analysis on NIH/3T3 cell lysates
using anti-Phospho-JNK1 (pY185) / JNK2 (pY185) /JNK3
(pY223) RabMAb (cat. #2155-1). Cells were either
(A) untreated (B) treated with Anisomycin.

Specificity
A synthetic phospho-peptide corresponding to
residues surrounding tyrosine 223 of human JNK3 was used
as immunogen. The antibody will detect JNK1 (pY185), JNK2(pY185) and JNK3 (pY223).
性状 【产品类型】Rabbit Monoclonal Antibody
【反应特异性】Human , Mouse , Rat
【克隆 ID】EP1597Y
【用途】WB , IP
【产品性状】
【阳性对照】
【产品浓度】
【细胞定位】
【抗原分子量】46kDa
贮存 Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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