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JAK3
英文名：JAK3
Cas号：
Cas号：
检测信息查询
| 货号 | 规格 | 货期 | 库存 | 价格 | 会员价 | 订购 |
| 1308114467-100ul | 现货 | 0 | ￥0 | 请登录 |
| 别 名 | Janus kinase 3, JAK-3, Leukocyte janus kinase, L-JAK |
| Cas号 | |
| M D L | |
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| 产品参数 | 【产品介绍】Jak3 is a member of the Janus family
tyrosine kinases (Jaks), whose function is to transduce extracellular signals from cytokines a n d interferons. Jaks associate with cytokine recept o r s; upon lig a n d binding, Jaks phosph o r ylate the recept o r . The phosph o r ylated recept o r s are bound by SH2-containing proteins, one class of which is the signal transducers a n d activat o r s of transcription (STATs). Activated STATs translocate to the nucleus to mediate gene transcription (1, 2). Jak3 is activated after binding to the gamma chain of Interleukin recept o r s, specifically IL-2, IL-4, IL-7, IL-9, a n d IL-15 recept o r s. Jak3 has been implicated in mast cell-mediated immediate hypersensitivity reactions, autoimmune dis o r ders, a n d acute lymphoblastic leukemia. Jak3 inhibit o r has shown clinical potential as a new class of immunomodulat o r y agents with anti-leukemic a n d immunosuppressive properties (3). WB: 1:2000 Flow Cytometry: 1:30 IP: 1:50 A. Western blot analysis on TF-1 cell lysate using anti-JAK3 RabMAb (cat. # 1785-1), dilution 1:2000 |
| 性状 | 【产品类型】Rabbit Monoclonal IgG
【反应特异性】Human 【克隆 ID】EP909Y 【用途】WB , FC , IP 【产品性状】 【阳性对照】 【产品浓度】 【细胞定位】 【抗原分子量】115 kDa |
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