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JAK3
英文名：JAK3
Cas号：
Cas号：
检测信息查询
| 货号 | 规格 | 货期 | 库存 | 价格 | 会员价 | 订购 |
| 1308114468-100ul | 现货 | 0 | ￥0 | 请登录 |
| 别 名 | JAK3 antibody, JAK-3 antibody, JAK3_HUMAN antibody, JAKL antibody, L-JAK antibody, LJAK antibody, Tyrosine-protein kinase JAK3 antibody, Leukocyte janus kinase antibody |
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| 产品参数 | 【产品介绍】JAK3 is a member of the Janus family
(JAK) tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. The JAK family is constitutively associated with cytokine receptors; upon binding to the receptor, the cytokine becomes phosphorylated (1). JAK also phosphorylates the cytokine receptor on tyrosine (Tyr) residues that serve as docking sites for cytoplasmic signal transducers and activators of transcription (STAT) proteins (2). Activated STATs translocate to the nucleus to mediate gene transcription (1). JAK3 is unique among JAK family members because it serves a function in normal lymphocyte development. In addition, JAK3 is the only one that interacts with the common gamma chain of the following Interleukin receptors: IL-2, IL-4, IL-7, IL-9, and IL-15 receptors (3). Loss of JAK3 function causes a severe block in T-cell and natural killer (NK) cell development (4). Defects in JAK3 are a cause of severe combined immunodeficiency (SCID), characterized by an absence of T-cell-mediated cellular immunity (5). Recommended Applications WB, ICC Applications and Recommended Dilution Factors WB: 1:1,000-10,000 ICC: 1:250 - 500 Species Reactivity Human Products Data Western blot analysis on (A) IM-9 and (B) TF-1 cell lysates using anti-JAK3 RabMAb (cat. # 2856-1). Specificity A synthetic peptide corresponding to residues on the N-terminus in human JAK3 was used as an immunogen. |
| 性状 | 【产品类型】Rabbit Monoclonal Antibody
【反应特异性】Human 【克隆 ID】EPR908(2) 【用途】WB , ICC 【产品性状】 【阳性对照】 【产品浓度】 【细胞定位】 【抗原分子量】115kDa |
| 贮存 | Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
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